Research progress on the role of adiponectin and its gene polymorphism in obstructive sleep apnea hypopnea syndrome
Chen Rongti
Shen Shuaijie
Zhu Song
Li Ping
Ping Fen
Abstract：Obstructive sleep apnea hypopnea syndrome(OSAHS)is a sleep disorder characterized by intermittent hypoxia,hypercapnia and sleep structure disorder caused by repeated upper airway obstruction,and is associated with cardio-cerebrovascular diseases and metabolic diseases,such as hypertension,coronary heart disease,diabetes,etc.In recent years,related studies have found that adiponectin is an adipokine with anti-inflammatory and anti-atherosclerotic effects.Many scholars have paid attention to the potential role of adiponectin in the occur-rence and development of OSAHS.It has been found that serum adiponectin levels are generally lower in patients with OSAHS,and this reduction correlates with disease severity and obesity.Continuous positive airway pressure treatment can increase serum adiponectin level and improve inflammatory state in patients with OSAHS to a certain extent,suggesting that adiponectin plays an important role in the pathogenesis of OSAHS.In addition,related studies have revealed that adiponectin gene polymorphism may affect its expression and function,thereby affecting the occurrence and development of OSAHS.This article reviews the latest research progress on the role of adipone-ctin in OSAHS and its genetic correlation,in order to provide new ideas and potential targets for the diagnosis and treatment of OSAHS.
Keywords：Obstructive sleep apnea hypopnea syndromeAdiponectinGene polymorphismDiagnosisTreatment
Publication Date：2025-02-07
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 303-307 )