A case analysis about drug use of acute exacerbation of chronic obstructive pulmonary disease with multidrug resistant bacterial infection
Zhang Li
Ren Qianling
Zhou Su
Yang Ping
Dong Yongchao
Abstract：This case report is of a patient with acute exacerbation of chronic obstructive pulmonary disease and multidrug resistant Pseudomonas aeruginosa infection.Moxalactam,ceftazidime and etimicin sulfate injection were given successively for anti-infective treatment,but the symptoms were not improved.Combined with the results of sputum culture suggesting Pseudomonas aeruginosa(mucoid type),the clinical pharmacist suggested adjusting the antibacterial drug to meropenem,and replacing sodium valproate sustained-release tablets with leveti-racetam tablets.Azithromycin tablets were added because the infection index of the patient was still high,although the infection index decreased after 3 d of treatment.After treatment,the symptoms and positive signs of the patient disappeared,and the patient was cured and discharged.Clinical pharmacists should actively communicate with clinicians according to the pharmacological effects,pharmacokinetics/pharmacodynamic characteristics of antibiotics,and auxiliary medication precautions in combination with the patient's condition and pathogenic characteristics,so as to develop personalized and accurate dosing regimens for patients and guide clinical rational drug use.
Keywords：Chronic obstructive pulmonary diseaseMultidrug resistantPseudomonas aeruginosa
Publication Date：2025-02-07
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 281-284 )