Study on the value of serum apolipoprotein C1,interleukin-6 and squamous cell carcinoma antigen in the diagnosis of cervical cancer

Zhang Peili; Ju Ying; Chen Lanlan; Liu Yiqing; Peng Meiyu

doi:10.3760/j.issn.1673-4777.2025.02.021

Abstract：Objective To investigate the diagnostic value of serum apolipoprotein C1(APOC1),inter-leukin-6(IL-6)and squamous cell carcinoma antigen(SCC)in cervical cancer.Methods A total of 74 patients with cervical cancer who were treated in the Provincial Hospital Affiliated to Shandong First Medical University from April 2023 to June 2024 were selected as the cervical cancer group,and 60 healthy people were selected as the control group.The levels of APOC1,IL-6 and SCC in the two groups were compared,and the relationship between serum APOC1,IL-6 and SCC levels and clinicopathological parameters in patients with cervical cancer was analyzed.The receiver operating characteristic curve was used to evaluate the diagnostic value of single and combined detection of APOC1,IL-6 and SCC for cervical cancer,and the risk degree of cervical cancer in patients with different serum expression levels was compared.Results The levels of APOC1,IL-6 and SCC in cervical cancer group were higher than those in control group[89.00(64.67,169.17)mg/L vs 46.84(27.78,64.15)mg/L,65.49(39.88,125.20)ng/L vs 34.04(22.28,55.35)ng/L,1.81(1.03,4.03)μg/L vs 1.01(0.76,1.50)μg/L](Z=6.130,5.096,4.779,all P＜0.001).The serum APOC1 and IL-6 levels in International Federation of Gynecology and Obstetrics(FIGO)stage Ⅲ patients were significantly higher than those in FIGO stage Ⅰ-Ⅱpatients.The serum APOC1 level in poorly differentiated patients was significantly higher than that in moderately well differentiated patients.The SCC level in squamous cell carcinoma patients was higher than that in adenocarci-noma patients(all P＜0.05).The area under the curve of combined detection of APOC1,IL-6 and SCC in the diagnosis of cervical cancer was larger than that of any one of them alone(0.900 vs 0.809,0.757,0.741),and the sensitivity and specificity of combined detection of the three markers were also higher than those of single detection(all P＜0.05).The risk of cervical cancer in patients with high levels of APOC1,IL-6 and SCC was 9.76,5.94 and 3.92 times higher than those with low levels of APOC1,IL-6 and SCC.Conclusions The serum levels of APOC1,IL-6 and SCC are significantly increased in patients with cervical cancer.The serum levels have certain predictive value for tumor stage,tumor type and differentiation degree.The combined detection of APOC1,IL-6 and SCC can improve the diagnostic efficiency of cervical cancer.