Effect of atorvastatin combined with metformin in the treatment of obese polycystic ovary syndrome
Wang Xin
Liu Lu
Zhang Xiaomei
Wang Yang
Yang Dan
Li Hui
Abstract：Objective To investigate the effect of atorvastatin combined with metformin in the treatment of obese polycystic ovary syndrome.Methods A total of 150 patients with obese polycystic ovary syndrome admitted to Shaanxi Provincial People's Hospital from September 2021 to October 2023 were consecutively recruited.According to the random number table method,all cases were divided into observation group and control group,with 75 cases in each group.The control group was treated with metformin,and the observation group was treated with atorvastatin combined with metformin.The total clinical effective rate,physical indicators,sex hormone indicators,lipid metabolism indicators,insulin resistance indicators and adverse reactions of the two groups were recorded.Results The total effective rate of the observation group was higher than that of the control group[90.7％(68/75)vs 78.7％(59/75)](P=0.041).After treatment,the waist circumference and body mass index of the two groups were lower than those before treatment,and the observation group were lower than those of the control group(all P＜0.05).After treatment,the levels of serum testosterone,luteinizing hormone and estradiol in the observation group were lower than those in the control group,and the level of follicle-stimulating hormone was higher than that in the control group(all P＜0.05).After treatment,the lipid metabolism indexes of the two groups were significantly improved compared with those before treatment,and the levels of total cholesterol,triglyc-eride,and low-density lipoprotein cholesterol in the observation group were significantly lower than those in the control group,while the high-density lipoprotein cholesterol level was higher than that in the control group(all P＜0.05).After treatment,the insulin resistance indexes of the two groups were significantly decreased,and the fasting blood glucose,fasting insulin,and homeostasis model insulin resistance index of the observation group were significantly lower than those of the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.575).Conclusion Atorvastatin combined with metformin is effective in the treatment of obese polycystic ovary syndrome,which can reduce the level of physical indicators,improve the level of sex hormones,lipid metabolism and insulin resistance,and the treatment safety is good.
Keywords：Polycystic ovary syndromeObese typeMetforminAtorvastatin
Publication Date：2025-02-07
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 255-259 )