Predictive efficacy of serum heme oxygenase-1 combined with Essen stroke risk score in patients with isolated vertigo complicated with cerebral infarction

Yang Chunyan; Li Tian; Zheng Xuejiao

doi:10.3760/j.issn.1673-4777.2025.02.009

Abstract：Objective To investigate the efficacy of heme oxygenase-1(HO-1)combined with Essen stroke risk score(ESRS)in predicting cerebral infarction in patients with isolated vertigo.Methods A total of 163 patients with isolated vertigo admitted to the First Affiliated Hospital of Xi'an Jiaotong University Yulin Hospital from February 2022 to February 2024 were selected as the research objects.According to the occurrence of cerebral infarction,they were divided into occurrence group(47 cases)and non-occurrence group(116 cases).The baseline data of the two groups were compared,and the levels of HO-1 and ESRS were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of cerebral infarction in patients with isolated vertigo.The receiver operating characteristic curve was used to analyze the predictive efficacy of HO-1 combined with ESRS in patients with isolated vertigo complicated with cerebral infarction.Results The proportion of hypertension and the level of interleukin-6(IL-6)were significantly higher in the occurrence group than those in the non-occurrence group(both P＜0.05).The level of HO-1 in the occurrence group was signifi-cantly lower than that in the non-occurrence group[(102±20)μg/L vs(240±35)μg/L],and the ESRS was significantly higher than that in the non-occurrence group[(5.5±2.1)vs(3.1±1.1)](both P＜0.001).Multivariate Logistic regression analysis showed that hypertension,increased levels of IL-6 and ESRS were independent risk factors for cerebral infarction in patients with isolated vertigo,and low level of HO-1 was an independent protective factor for cerebral infarction in patients with isolated vertigo(all P＜0.001).The sensitivity and specificity of the combined detection of HO-1 and ESRS in the diagnosis of cerebral infarction in patients with isolated vertigo were 89.36％and 87.07％,respectively,and the area under the curve of the combined detection of HO-1 and ESRS was significantly greater than those of the single detection(both P＜0.05).Conclusion The level of HO-1 in patients with isolated vertigo complicated with cerebral infarction is significantly decreased,and the ESRS is significantly increased.The combination of HO-1 and ESRS has a high predictive value for the diagnosis of isolated vertigo complicated with cerebral infarction.