Evaluation of the prognostic value of heparin-binding protein,neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with community-acquired pneumonia

Yang Aiyue; Wang Qing

doi:10.3760/j.issn.1673-4777.2025.02.008

Abstract：Objective To investigate the prognostic value of heparin-binding protein,neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in patients with community-acquired pneumonia(CAP).Methods A total of 115 CAP patients admitted to Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University from November 2022 to November 2023 were selected as observa-tion objects.The patients were followed up for 28 days after discharge.According to the survival situation,the patients were divided into good prognosis group(94 cases)and poor prognosis group(21 cases).The general data and laboratory indexes of the two groups were collected and compared.Logistic regression was used to analyze the risk factors of poor prognosis in CAP patients.The receiver operating characteristic curve was used to analyze the value of heparin-binding protein,NLR,PLR alone and the combination of other indicators in evaluating the poor prognosis of CAP patients.Results There were no significant differences in gender,age,body mass index,smoking history,drinking history,diabetes mellitus history,diastolic blood pressure,systolic blood pressure,urea nitrogen,creatinine,alanine aminotransferase,aspartate aminotransferase between the two groups(all P＞0.05).The clinical pulmonary infection score,interleukin-6,C-reactive protein,procalcitonin,white blood cell count,heparin-binding protein,NLR and PLR in the poor prognosis group were higher than those in the good prognosis group(all P＜0.05).Multivariate Logistic regression analysis showed that clinical pulmonary infection score,interleukin-6,C-reactive protein,procalcitonin,white blood cell count,heparin-binding protein,NLR and PLR were all risk factors for poor prognosis of CAP patients(all P＜0.05).The results of receiver operating characteristic curve analysis showed that the area under the curve of heparin-binding protein,NLR,and PLR for evaluating the poor prognosis of CAP patients was 0.884,0.880,and 0.895,respectively,and the sensitivity was 0.714,0.762,and 0.810,respectively.The area under the curve of the three factors combined to evaluate the poor prognosis of CAP patients was 0.974,and the sensitivity was 0.905.Conclusion There are many and complex risk factors for poor prognosis of CAP patients.Heparin-binding protein,NLR and PLR have high value in the prognosis evaluation of CAP patients.