Clinical study on the safety and efficacy of high-flow nasal cannula oxygen therapy in patients with acute exacerbation of chronic heart failure

Liu Chunyan; Fan Yalin; Li Dongxu; Su Xueping

doi:10.3760/j.issn.1673-4777.2025.02.004

Abstract：Objective To investigate the efficacy and safety of high-flow nasal cannula oxygen therapy(HFNCO)in emergency patients with acute exacerbation of chronic heart failure.Methods A total of 63 patients with acute exacerbation of chronic heart failure admitted to the Department of Emergency,the 980th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from January 1,2020 to December 31,2021 were selected and divided into HFNCO group and non-invasive ventilation(NIV)group according to the random number table method.The general condition,oxygenation index and cardiac function related index were observed and compared between the two groups when they entered and left the emergency department.Results Arterial partial pressure of carbon dioxide was significantly lower in the HFNCO group than in the NIV group at discharge from the emergency department[(38±4)mmHg vs(41±5)mmHg](P=0.015).Compared with those at the time of admission to the emergency department,the arterial oxygen partial pressure of patients in the HFNCO group and the NIV group was significantly improved at the time of leaving the emergency department[(74±8)mmHg vs(68±9)mmHg,(75±7)mmHg vs(69±12)mmHg](both P＜0.05).Cardiac index,stroke volume,and stroke volume index were significantly lower in the HFNCO group than in the NIV group at discharge from the emergency department(all P＜0.05).Cardiac output,cardiac index,stroke volume,and stroke volume index were significantly increased at the time of leaving the emergency department in both HFNCO and NIV groups compared with those at the time of admission(all P＜0.05).There were no statistically significant differences in the success rate of ventilation and emergency room stay time between the two groups(both P＞0.05).Conclusion HFNCO can improve oxygenation index and cardiac function in emergency patients with acute exacerbation of chronic heart failure.