Study on the correlation between pan-immune inflammation value and left ventricular remodeling and poor prognosis in elderly patients with chronic heart failure

Pei Shujuan; Liu Fang; Guan Lihong; Wang Qiang; Wan Qin; Chen Gongcai

doi:10.3760/j.issn.1673-4777.2025.02.003

Abstract：Objective To investigate the correlation between pan-immune inflammation value(PIIV)and left ventricular remodeling and poor prognosis in elderly patients with chronic heart failure.Methods This study was a retrospective analysis.A total of 150 elderly patients with chronic heart failure admitted to the 908th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from January 2020 to December 2021 were collected as the chronic heart failure group.In addition,150 relatively healthy elderly volunteers who under-went physical examination in our hospital during the same period were collected as the control group.The chronic heart failure group was further divided into subgroups according to the level of PIIV.The differences in clinical data between the different groups were compared,and the correlation between PIIV and related indicators of ventricular remodeling and its efficacy in predicting left ventricular remodeling in elderly patients with chronic heart failure were analyzed.At the same time,the related factors of left ventricular remodeling in elderly patients with chronic heart failure were analyzed.Results The PIIV of patients in the chronic heart failure group was significantly higher than that in the control group[687.4(472.1,856.9)vs 305.1(185.4,440.6)](P＜0.05).According to the median of PIIV in the chronic heart failure group,the patients in the chronic heart failure group were divided into low PIIV group(PIIV≤687.4,n=75)and high PIIV group(PIIV＞687.4,n=75).The incidence of left ventricular remodeling,left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)in the high PIIV group were higher/greater than those in the low PIIV group,and left ventricular ejection fraction(LVEF)in the high PIIV group was lower than that in the low PIIV group[61.3％(46/75)vs 41.3％(31/75),(198±17)ml vs(186±12)ml,(230±15)ml vs(219±14)ml,(42±11)％vs(47±8)％](all P＜0.05).The rates of recurrent heart failure and cardiac rehospitalization in the high PIIV group were higher than those in the low PIIV group[54.7％(41/75)vs 33.3％(25/75),41.3％(31/75)vs 22.7％(17/75)](both P＜0.05).PIIV was significantly positively correlated with LVESV and LVEDV(r=0.502,0.542,both P＜0.001),and negatively correlated with LVEF(r=-0.533,P＜0.001).The area under the receiver operating characteristic curve of PIIV for predicting left ventricular remodeling in elderly patients with chronic heart failure was 0.869,with a 95％confidence interval of 0.822-0.916.Multivariate COX regression analysis showed that PIIV,New York Heart Association functional class and N-terminal pro-brain natriuretic peptide were the influencing factors of left ventricular remodeling in patients with chronic heart failure(all P＜0.05).Conclusion PIIV has a good predictive value for left ventricular remodeling in elderly patients with chronic heart failure.