The correlation of neutrophil to lymphocyte ratio and systemic immune inflammation index with carotid atherosclerosis

Nigeer Aibaidula; Zheng Yingying

doi:10.3760/j.issn.1673-4777.2025.01.011

Abstract：Objective To investigate the correlation between neutrophil to lymphocyte ratio(NLR),systemic immune inflammation index(SII)and carotid atherosclerosis(CAS),and their predictive value for CAS.Methods A total of 400 patients who were treated in the heart center of the First Affiliated Hospital of Xinjiang Medical University from January 2020 to January 2023 were selected,and they were divided into CAS group(157 cases)and non-CAS group(243 cases)according to the results of carotid ultrasound.The CAS group was further divided into carotid intima-media thickening group,single plaque group and multiple plaque group according to the carotid plaque.The basic clinical data,blood routine and blood biochemical indexes of each group were compared,and the correlation between the number of plaques and Crouse score in CAS group was analyzed.Multivariate Logistic regression was used to analyze the independent risk factors of CAS.The receiver operating characteristic(ROC)curve was used to analyze the value of NLR,SII alone and combined in predicting CAS.Results The age,systolic blood pressure,Crouse score,smoking history,history of hypertension,history of coronary atherosclerotic heart disease,history of diabetes mellitus,and proportion of recent use of lipid-lowering drugs in the CAS group were higher than those in the non-CAS group(all P＜0.05).NLR and SII in CAS group were higher than those in non-CAS group[(2.2±0.9)vs(1.8±0.7),(506±229)vs(418±157)](both P＜0.05).Triglyceride,low-density lipoprotein cholesterol(LDL-C),fasting blood glucose and glycosylated hemoglobin(HbA1c)in the CAS group were higher than those in the non-CAS group(all P＜0.05).Crouse score of multiple plaque group was higher than that of single plaque group(P＜0.05).Multivariate Logistic regression analysis showed that coronary atherosclerotic heart disease,NLR,SII,triglyceride,LDL-C and HbA1c were independent risk factors for CAS(all P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of NLR for predicting CAS was 0.62(95％confidence interval:0.57-0.68),and the AUC of SII for predicting CAS was 0.60(95％confidence interval:0.54-0.65),and the AUC for predicting CAS increased to 0.72(95％confidence interval:0.67-0.77)when the two were combined.Conclusion NLR and SII are closely related to the occurrence of CAS,and both have certain predictive value for CAS.The predictive value of CAS can be improved when NLR and SII are combined.