Research progress of cellular metabolism in the pathogenesis and treatment of rheumatoid arthritis
Zhang Rui
Zhang Li
Mao Jing
Li Wenhua
Zhang Xianmeng
Shen Haili
Abstract：Rheumatoid arthritis(RA)is a chronic systemic immune disease characterized by synovial inflammation and progressive joint destruction.Disorders of cell metabolism are closely related to the pathology of RA.At the site of inflammation,due to the limitation of energy sources,inflammatory cells adapt to perform their homeostatic functions through metabolism.Metabolic abnormalities in immune cells and stromal cells are considered to be important drivers of chronic inflammation in RA.Metabolites such as lactate play a key role in regulating immune cell function.This article reviews the important role of glycolysis,mitochondrial metabolism,lipid and amino acid metabolism in RA and the current status of metabolic-targeted therapy,in order to provide new ideas for the treatment of RA.
Keywords：Rheumatoid arthritisImmune cellsMetabolic disordersTargeted therapy
Publication Date：2024-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1908-1911 )