The effect of modified Xinglou Chengqi decoction combined with butylphthalide in the treatment of cognitive impairment after cerebral infarction and its influence on serum brain-gut peptide factor,homocysteine and β-amyloid protein 1-42 levels
Wang Nan
Song Yuehan
Yang Yuejun
Chen Xuan
Liu Tao
Abstract：Objective To investigate the effect of modified Xinglou Chengqi decoction combined with butylphthalide in the treatment of cognitive impairment after cerebral infarction and its influence on serum brain-gut peptide factor,homocysteine(Hey)and β-amyloid protein 1-42(Aβ1-42).Methods A total of 120 patients with cognitive impairment after cerebral infarction admitted to the No.2 Hospital of Baoding,Hebei Province from January 2019 to November 2023 were selected.They were divided into combined group,Chengqi decoction group and butylphthalide group according to the random number table method,with 40 cases in each group.All the three groups were given conventional western medicine treatment,including cranial nerve nutrition,anti-platelet aggrega-tion,and improving circulation.Butylphthalide group was treated with butylphthalide.The Chengqi decoction group was treated with modified Xinglou Chengqi decoction.The combined group was treated with modified Xinglou Chengqi decoction and butylphthalide,and the three groups were treated for 4 weeks.The efficacy of traditional Chinese medicine,western medicine,neurological function,cognitive function,daily living ability,brain-gut peptide factor,Hcy,Aβ1-42,and the incidence of adverse reactions were compared among the three groups.Results The total effective rate of traditional Chinese and western medicine treatment in the combined group were higher than those in the butylphthalide group and the Chengqi decoction group,and the total effective rate of tradi-tional Chinese medicine treatment in the Chengqi decoction group was higher than that in the butylphthalide group(all P＜0.05).After treatment,the neurological function score of the combined group was lower than those of the Chengqi decoction group and the butylphthalide group,and the Montreal cognitive Assessment scale score and daily living ability score were higher than those of the Chengqi decoction group and the butylphthalide group(all P＜0.05).After treatment,the levels of CGRP,5-hydroxytryptamine and motilin in combined group were higher than those in Chengqi decoction group and butylphthalide group(all P＜0.05).After treatment,Hey in the combined group was lower than that in the Chengqi decoction group and butylphthalide group,and Aβ1-42 was higher than that in the Chengqi decoction group and butylphthalide group(all P＜0.05).There was no significant difference in the total incidence of adverse reactions among the combined group,Chengqi decoction group and butylphthalide group[5.0％(2/40)vs 2.5％(1/40),5.0％(2/40)](x2=0.417,P=0.812).Conclusion Modified Xinglou Chengqi decoction combined with butylphthalide is effective in the treatment of cognitive impairment after cerebral infarction,which can regulate the expression of brain-gut peptide factors,improve neurological function and cognitive function,and improve the ability of daily living of patients,with high safety.
Keywords：Cerebral infarctionCognitive impairmentModified Xinglou Chengqi decoctionButylphthalideβ-amyloid protein 1-42
Publication Date：2024-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1851-1856 )