A randomized controlled study of analgesic effect of hydromorphone and dezocine in patients with non-mechanical ventilation in intensive care unit
Liu Jintao
Pan Xianguo
Yang Tao
Zhao Zhuqing
Wang Shaohong
Abstract：Objective To investigate the analgesic effects of hydromorphone and dezocine in patients with non-mechanical ventilation in intensive care unit(ICU).Methods A total of 94 ICU patients with non-mechanical ventilation admitted to the Second Affiliated Hospital of Guizhou Medical University from October 2021 to April 2024 were selected as the research objects.The patients were divided into control group and observation group by single-blind test method,with 47 cases in each group.The control group was treated with dezocine injection,and the observation group was treated with hydromorphone hydrochloride injection.The analgesic effect,sedative effect,comfort,pain factor levels,incidence of adverse events,and treatment safety were compared between the two groups.Results After treatment,the visual analogue scale score and Ricmond agitation sedation score at 12,24,48 and 72 h in the observation group were lower than those in the control group(all P＜0.05).After treat-ment,the physiological comfort,psychological comfort,environmental comfort,social and cultural comfort scores of the observation group were higher than those of the control group(all P＜0.05).After treatment,the levels of cyclooxygenase-2,bradykinin and prostaglandin E2 in the observation group were lower than those in the control group(all P＜0.001).The total incidence of adverse events in the observation group was lower than that in the control group[6.4％(3/47)vs 21.3％(10/47)](x2=4.376,P=0.034).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.726).Conclusion Compared with dezocine,hydromorphone has better analgesic and sedative effect for ICU patients without mechanical ventilation,which can improve the comfort of patients,reduce the level of pain factors,reduce the incidence of adverse events,and has good safety.
Keywords：Non-mechanical ventilationIntensive care unitHydromorphoneDezocineAnalgesia
Publication Date：2024-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1821-1825 )