Relationship between serum osteopontin and interleukin-17 expression and prognosis of triple-negative breast cancer after surgical treatment

Luo Yihong; Liang Jiahua; Li Hanlu; Du Junxian; Zhang Hongwei

doi:10.3760/j.issn.1673-4777.2024.12.012

Abstract：Objective To investigate the relationship between serum osteopontin and interleukin-17(IL-17)expression and the prognosis of triple-negative breast cancer(TNBC).Methods The clinical data and serum samples of 102 TNBC patients who underwent surgical treatment in Zhongshan Hospital Affiliated Fudan University from May 2018 to May 2021 were collected.Totally 18(17.6％)TNBC patients who had recurrence or metastasis within 3 years after surgery were classified into the poor prognosis group,and the remaining 84(82.4％)TNBC patients were classified into the good prognosis group.The relationship between serum osteopontin and IL-17 and the prognosis of TNBC after surgery were analyzed by dose-response relationship,interaction and receiver operating characteristic(ROC)curve.Results The levels of serum osteopontin and IL-17 in the poor prognosis group were higher than those in the good prognosis group[(99±12)μg/L vs(85±11)µg/L,(43±4)ng/L vs(37±4)ng/L](both P＜0.05).The analysis of restricted cubic spline showed that the serum levels of osteopontin and IL-17 had a non-linear dose-response relationship with the prognosis of TNBC patients treated with surgery(all P＜0.05).When the serum levels of osteopontin and IL-17 were＞85.12 μg/L and＞37.40 ng/L,respectively,the risk of poor prognosis increased with the increase of the levels of the indexes.After adjusting the confounding factors,there was a positive interaction between serum osteopontin and IL-17 on the prognosis of TNBC treated with surgery.When both of them were overexpressed,the risk of poor prognosis was 13.000 times as high as that when both were low.When both of them were overexpressed,the risk of poor prognosis was 11.307 times as high as that of other factors.The synergistic effect was 5.198 times of the sum of the effects of the two alone,and 75.38％of the risk of their coexistence was caused by their interaction.ROC curve analysis showed that the area under the curve of serum osteopontin,IL-17 and their combination for predicting the prognosis of TNBC after surgery was 0.810,0.826 and 0.891,respectively.The value of combined prediction was better than that of single prediction(both P＜0.05).Conclusions Serum osteopontin and IL-17 are related to the prognosis of TNBC after surgical treatment.High expression of serum osteopontin and IL-17 May increase the risk of poor prognosis of TNBC after surgical treatment.There is a positive interaction between the two factors,which synergistically increases the risk of poor prognosis of TNBC after surgical treatment,which should be paid attention to in clinical practice.