Analysis of the application value of clinical,ultrasound radiomics and fusion model in evaluating the clinical course of Hashimoto's thyroiditis

He Chaoying; Guo Peixin; Du Muxuan; Zhang Zhandong; Dai Zhibing

doi:10.3760/j.issn.1673-4777.2024.12.007

Abstract：Objective To analyze the application value of clinical,ultrasound radiomics and fusion model in evaluating the clinical course of Hashimoto's thyroiditis(HT).Methods The retrospective analysis method was used in this article.The clinical data of 80 patients with HT admitted to the Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University from February to November 2023 were collected.The patients were included in the observation group and randomly divided into a training set(50 cases)and a validation set(30 cases).Another 80 healthy people in the same period were selected as the control group.The clinical data and ultrasound radiomics features of the two sets of patients were compared.The radiomics model was established.The independent risk factors affecting the clinical course of patients were analyzed by univariate and multivariate regression methods.The clinical ultrasound radiomics fusion model was constructed,and the calibration curve,receiver operating characteristic(ROC)curve and clinical decision curve were used to evaluate the efficacy of the model.Results There was no significant difference in clinical data and ultrasound radiomics features between the two sets of patients(all P＞0.05).Multivariate analysis showed that thyroid stimulating hormone,free thyroxine,thyroid peroxidase antibody,thyroglobulin antibody,gland enlargement,diffuse hypoechoic and shear wave velocity were independent risk factors affecting the clinical course of HT patients(all P＜0.05).The sensitivity of the fusion model(area under the curve:0.807)was 73.19％,the specificity was 72.65％,and the accuracy was 74.28％,and the area under the curve was higher than that of the clinical model and ultrasound radiomics model(0.718 and 0.741).The results of calibration curve and clinical decision curve showed that the fitting effect of the fusion model was significant,and the consistency index was 0.866(95％confidence interval:0.702-0.943),and its prediction performance was good.Conclusion The application value of the fusion model in the evaluation of the clinical process of HT is higher than those of clinical and ultrasound radiomics alone,and it can be used as a clinical basis for predicting the clinical process of HT patients.