Correlation analysis of serum cystatin C and uric acid levels with bone mineral density in patients with type 2 diabetes mellitus in Qinghai region

Xie Yanling; Song Kang; Lin Lijun; Yao Yongli

doi:10.3760/j.issn.1673-4777.2024.12.006

Abstract：Objective To investigate the correlation of serum cystatin C and uric acid levels with bone mineral density in patients with type 2 diabetes mellitus(T2DM)in Qinghai region.Methods A total of 141 T2DM patients who were treated in the Department of Endocrinology,Qinghai Provincial People's Hospital from January to December 2023 were selected.According to the diagnostic criteria of osteoporosis,the patients were divided into normal bone mass group(56 cases),osteopenia group(53 cases)and osteoporosis group(32 cases).The general data of the patients were collected,serum cystatin C,uric acid and other biochemical indicators and bone mineral density data were measured,and the correlation between related indicators and bone mineral density was analyzed.Results There were significant differences in gender distribution,age,and levels of 25-hydroxyvi-tamin D,cystatin C,total cholesterol,and high-density lipoprotein cholesterol among the three groups(all P＜0.05).The variables with statistically significant differences in univariate analysis were included in the multivariate ordinal Logistic regression analysis model as independent variables.The results showed that age and cystatin C were risk factors for osteopenia and osteoporosis,while male sex and 25-hydroxyvitamin D were protective factors(odds ratios=0.434,0.922,1.100,3.555,all P＜0.05).Conclusion High level of serum cystatin C,female,old age and low level of 25-hydroxyvitamin D may be risk factors for osteopenia and osteoporosis in T2 DM patients in Qinghai province.There is no significant correlation between serum uric acid level and bone mineral density in T2DM patients.