Analysis of the influencing factors of pulmonary artery pressure improvement after transcatheter aortic valve implantation in patients with aortic stenosis and pulmonary hypertension
Du Yue
Liu Jinfeng
Li Xiaoming
Wu Shan
Yu Huimei
Tang Lili
Xie Meng
Zhang Chun
Abstract：Objective To investigate the improvement of pulmonary arterial hypertension(PAH)in patients with aortic stenosis(AS)and PAH after transcatheter aortic valve implantation(TAVI)and analyze the related factors.Methods A total of 168 AS patients with PAH undergoing TAVI in Beijing Anzhen Hospital,Capital Medical University from January 2022 to December 2023 were retrospectively analyzed.According to the pulmonary artery pressure 1 month after surgery,the patients were divided into PAH improvement group and PAH non-improvement group.The preoperative general data and echocardiographic parameters of the two groups were compared,and the influencing factors of the improvement of PAH after operation were analyzed.Results Among 168 patients,123 patients(73.2％)had improvement in PAH after surgery(PAH improvement group),and 45 patients(26.8％)did not improve(PAH non-improvement group).There were significant differences in atrial fibrillation,left atrial diameter(LAD),left ventricular end-diastolic diameter,left ventricular end-diastolic volume,left ventricular end-systolic volume,and moderate or severe tricuspid regurgitation(TR)between the two groups(all P＜0.05).Multivariate Logistic regression analysis showed that atrial fibrillation(odds ratio=0.444,95％confidence interval:0.201-0.981,P=0.045),LAD(odds ratio=1.086,95％confidence interval:1.008-1.169,P=0.029),combined with moderate or severe TR(odds ratio=0.428,95％confidence interval:0.189-0.967,P=0.041)were independent influencing factors for the improvement of PAH after TAVI.Conclusions TAVI can effectively improve the degree of PAH in AS patients with PAH.Preoperative atrial fibrillation,preoperative LAD and moderate or severe TR are the influencing factors for the improvement of PAH after TAVI.
Keywords：Aortic valve stenosisTranscatheter aortic valve implantationPulmonary arterial hypertensionEchocardiography
Publication Date：2024-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1761-1765 )