Advances in the application of hydroxychloroquine in the treatment of kidney diseases
Wang Yao
Bai Yihua
Yang Huan
Xiao Liying
Qiu Jie
He Zhenkun
Abstract：Hydroxychloroquine,as an antimalarial drug,has low toxicity,anti-inflammatory,immuno-modulatory,immunosuppressive and thromboprophylaxis effects.It is not only used in the treatment of malaria,but also in the treatment of rheumatic immune diseases.As the research progressed,it is discovered that hydroxychloro-quine can mitigate kidney damage by inhibiting the cascade of inflammatory signaling,suppressing autophagy,and preventing the formation of immune response complexes,thereby reducing or delaying the occurrence of proteinuria.Hence,it is utilized for the management of kidney diseases associated with inflammatory responses,such as IgA nephropathy and lupus nephritis.Moreover,hydroxychloroquine has demonstrated a superior safety profile in comparison to other immunosuppressants for treating kidney diseases.Furthermore,the therapeutic efficacy of hydroxychloroquine in additional kidney conditions like diabetic nephropathy and membranous nephropathy is highly esteemed,warranting further investigation into its mechanism of action and potential safety considerations.
Keywords：Kidney diseasesIgA nephropathyLupus nephritisHydroxychloroquine
Publication Date：2024-11-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1752-1755 )