Potential research progress of adjuvant hypoxic therapy in the management of myocardial infarction

Jiao Yuemiao; Qiang Guifen; Zhao Li; Yin Chengqian

doi:10.3760/j.issn.1673-4777.2024.11.025

Abstract：Myocardial infarction remains a major public health challenge,and despite advances in acute treatment and long-term management,the search for innovative therapies to enhance outcomes and improve patient outcomes and quality of life continues.Even though surgical treatment has been quite mature,the incidence of postoperative complications in patients with myocardial infarction is still high,which prompts the medical commu-nity to begin to seek adjuvant treatment options.Oxygen therapy was considered the cornerstone of the treatment of myocardial infarction in the 20th century,but emerging evidence has revealed its limited effectiveness and potential adverse effects in patients with normal oxygen saturation,and this approach is no longer recommended for routine use.Therefore,hypoxia therapy has become a highly anticipated emerging method.Hypoxic adjuvant therapy is to induce adaptive response by exposing patients to hypoxic environment in a controlled and intermittent manner,so as to improve myocardial metabolism,enhance vascular function,and improve exercise endurance.The underlying mechanisms of this therapy involve stabilizing hypoxia-inducible factors,stimulating angiogenesis,and reducing oxidative stress,thereby protecting against ischemic injury and promoting cardiac repair.In conclusion,adjuvant hypoxic therapy provides a promising new approach for the management of myocardial infarction,but more studies are needed to optimize its application and ensure its safety and efficacy.