Correlation of serum visfatin and adiponectin levels with clinical features of pediatric febrile seizures and conversion to epilepsy
Chen Yawen
Wang Yiyuan
Zha Xiaowen
Li Lei
Xiang Genfang
Hu Yan
Tan Xiaofei
Abstract：Objective To investigate the correlation of serum visfatin and adiponectin levels with clinical features of pediatric febrile seizures(FS)and conversion to epilepsy.Methods A total of 228 children with FS admitted to Department of Emergency,the First Hospital of Hunan University of Chinese Medicine from January 2021 to June 2023 were selected as the FS group,and 114 children with fever and 114 healthy children during the same period were selected as the fever group and the control group,respectively.The serum levels of visfatin and adiponectin were compared among the three groups.Logistic regression was used to analyze the influencing factors of FS converting to epilepsy.The receiver operating characteristic curve was used to evaluate the predictive value of serum visfatin and adiponectin levels for the conversion of FS to epilepsy in children.Results The serum level of visfatin in the control group,fever group and FS group decreased in turn,and the serum level of adiponectin increased in turn in the control group,fever group and FS group(all P＜0.05).The serum levels of visfatin and adiponectin were related to the type of FS,the duration of seizures,and the number of seizures within 24 h(all P＜0.05).After 1 year of follow-up,the incidence of epilepsy in 228 FS children was 25.0％(57/228).Complex FS,the duration of seizure ≥15 min,the number of seizure within 24 h ≥2,and high level of adiponectin were independent risk factors for the conversion of FS to epilepsy,and high level of visfatin was an independent protective factor(all P＜0.05).The area under the curve of serum visfatin combined with adiponectin in predicting FS to epilepsy was 0.872,which was larger than 0.787 and 0.790 predicted by serum visfatin or adiponectin alone(both P＜0.05).Conclusions The decreased level of serum visfatin and the increased level of serum adiponectin are related to the type of FS,the duration and frequency of seizures in children,and are independent factors affecting the conversion of FS to epilepsy.The combination of visfatin and adiponectin has a high value in predicting the conversion of FS to epilepsy in children.
Keywords：Pediatric febrile seizuresEpilepsyVisfatinAdiponectin
Publication Date：2024-11-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1702-1707 )