Observation on the effect of glucosamine hydrochloride tablets combined with traditional Chinese medicine preparations fragrant tablets in the prevention and treatment of mild to moderate knee osteoarthritis

Tang Chengjie; Zhang Huiwu; Liu Jingjing; Pan Qing; Pan Runan; Li Feng

doi:10.3760/j.issn.1673-4777.2024.11.019

Abstract：Objective To observe the effect of glucosamine hydrochloride tablets combined with traditional Chinese medicine preparations fragrant tablets in the prevention and treatment of mild to moderate knee osteoarthritis(KOA).Methods A total of 110 patients with mild to moderate KO A admitted to Sichuan Province Orthopedic Hospital from May 2021 to December 2023 were selected.They were completely randomized into conventional group and combination group,with 55 cases in each group.The conventional group was treated with glucosamine hydrochloride tablets,while the combination group was treated with traditional Chinese medicine preparations fragrant tablets in addition to the conventional group.The knee joint pain visual analogue scale(VAS)score,osteoarthritis index score of Western Ontario and McMaster Universities(WOMAC),knee joint function,daily living activity,clinical efficacy,and adverse reactions were compared between two groups.Results After treatment,the VAS scores of both groups were lower than those before treatment,and the combination group was significantly lower than the conventional group[(2.4±0.6)vs(3.2±1.3)],with a statistically significant difference(t=3.491,P=0.003).After treatment,the WOMAC score of the combined group was lower than that of the conventional group,and the range of motion score in the Lysholm knee joint function score was higher in the combined group than in the conventional group,with statistically significant differences(all P＜0.05).At 6 months of treatment,the activities of daily living score of the combination group was higher than that of the conventional group[(95±5)vs(77±5)],and the difference was statistically significant(t=19.986,P＜0.001).The total effective rate of the combined group was higher than that of the conventional group[90.9％(50/55)vs 76.4％(42/55)],and the difference was statistically significant(x2=4.251,P=0.039).No serious adverse reactions occurred in both groups.Conclusions The combination of glucosamine hydrochloride tablets and traditional Chinese medicine preparations fragrant tablets can effectively promote pain relief,improve activities of daily living and knee joint function,reduce limited knee joint mobility,and is safe and effective in the treatment of mild to moderate knee osteoarthritis.