The predictive value of serum fetuin A,fatty acid binding protein 4 and microRNA-31 for pregnancy outcome of gestational diabetes mellitus

Gong Lina; Shi Haiheng; Zhang Yanmei; Sui Shuang; Huang Ying

doi:10.3760/j.issn.1673-4777.2024.11.014

Abstract：Objective To investigate the relationship between serum fetuin A,fatty acid binding protein 4(FABP4)and microRNA-31(miR-31)with gestational diabetes mellitus(GDM)and their predictive value for pregnancy outcome.Methods A total of 120 GDM patients admitted to Xinjiang Uygur Autonomous Region People's Hospital from January 2022 to March 2023 were selected as the observation group,and 120 healthy pregnant women were selected as the control group.The serum levels of fetuin A,FABP4 and miR-31 in the two groups were detected,and the correlation between the levels of fetuin A,FABP4 and miR-31 and insulin resistance index(HOMA-IR)in patients with different clinical characteristics was analyzed,and the value of predicting adverse pregnancy outcomes was analyzed.Results The levels of serum fetuin A,FABP4 and miR-31 in the observation group were higher than those in the control group[(40±10)μg/L vs(30±7)μg/L,(27.1±3.6)mg/L vs(15.6±2.9)mg/L,(2.03±0.41)vs(1.00±0.26)](all P＜0.001).In the observation group,the levels of fetuin A,FABP4 and miR-31 in patients with HOMA-IR ≥5 and adverse pregnancy outcomes were higher than those in patients with HOMA-IR＜5 and without adverse pregnancy outcomes(all P＜0.05).Serum fetuin A,FABP4 and miR-31 were positively correlated with HOMA-IR in the observation group(all P＜0.001).The areas under the receiver operating characteristic curve of serum fetuin A,FABP4 and miR-31 for predicting adverse pregnancy outcomes were 0.733,0.831,and 0.824,respectively.Conclusion Serum fetuin A,FABP4 and miR-31 levels are increased in patients with gestational diabetes mellitus,which are positively correlated with HOMA-IR,and have certain application value in predicting adverse pregnancy outcomes.