The clinical application value of serum 25-hydroxy vitamin D and interleukin-6 in patients with type 2 diabetes mellitus complicated with different degrees of non-alcoholic fatty liver disease
Shao Ning
Ma Jing
Liang Guimin
Chen Ping
Wu Donghong
Liu Jie
Abstract：Objective To analyze the clinical application value of serum 25-hydroxy vitamin D[25-(OH)D]and interleukin-6(IL-6)in patients with type 2 diabetes mellitus(T2 DM)complicated with different degrees of non-alcoholic fatty liver disease(NAFLD).Methods From January to December 2023,90 inpatients and outpatients with T2DM or T2DM combined with NAFLD(case group)in the First Hospital of Harbin,Heilongjiang Province and 30 healthy people in the same period were selected as the research objects.In this study,30 healthy people who underwent physical examination during the same period were set as group A.The case group was divided into group B,group C and group D according to the results of liver color Doppler ultrasound and liver function test,with 30 cases in each group.Group B was T2DM without NAFLD,group C was T2DM with NAFLD but without abnormal liver function,and group D was T2DM with NAFLD and abnormal liver function.The changes of25-(OH)D and IL-6 levels in each group were compared,and the correlation between them and related metabolic indexes was analyzed.Results The levels of serum 25-(OH)D in group D were significantly lower than those in group A,group B and group C,while the levels of serum IL-6 in group D were significantly higher than those in groups A,B and C[(12.3±5.9)μg/L vs(23.7±2.5),(20.0±5.2),(16.0±3.1)μg/L;(12.9±4.8)ng/Lvs(3.8±2.0),(5.5±3.0),(8.0±5.3)ng/L](all P＜0.05).The levels of serum 25-(OH)D in group C were lower than those in group A and group B,while the levels of serum IL-6 were higher than those in group A and group B(all P＜0.05).The level of serum 25-(OH)D in group B was lower than that in group A(P＜0.05).Serum 25-(OH)D level was negatively correlated with IL-6,body weight,body mass index,waist circumference,hip circumference,systolic blood pressure,glycosylated hemoglobin(HbA1c),fasting blood glucose,2 h postprandial blood glucose(2 hPG),alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(γ-GGT),total cholesterol,triglyceride,fasting insulin(FINS),and homeo-stasis model assessment insulin resistance index(HOMA-IR)(all P＜0.05).IL-6 level was positively correlated with body weight,body mass index,waist circumference,hip circumference,HbA1c,fasting blood glucose,2 hPG,ALT,AST,γ-GGT,total cholesterol,triglyceride,β2-microglobulin,serum creatinine,FINS and HOMA-IR(all P＜0.05).Conclusions The level of serum 25-(OH)D is significantly decreased and the level of IL-6 is significantly increased in T2DM patients with NAFLD.Serum 25-(OH)D and IL-6 levels are related to a number of metabolic indicators.Combined detection of the two indicators is helpful for early monitoring of the disease and timely taking measures to prevent or delay the occurrence and development of T2DM combined with NAFLD.
Keywords：Type 2 diabetes mellitusNon-alcoholic fatty liver disease25-hydroxyl vitamin DInterleukin-6
Publication Date：2024-11-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1659-1663 )