Overview of the role of granzyme B in autoimmune diseases
Yang Zixuan
Pan Lili
Li Taotao
Abstract：Autoimmune diseases(AID)are a group of chronic inflammatory diseases caused by autoim-mune imbalance involving multiple systems.The disease is widespread in the population,the etiology is unknown,and it has a great impact on the health of the patients themselves and the whole people.Granzyme B,a serine protease,can cleave a wide range of substrates inside and outside the cell,which may be an important factor affecting the development of AID.At present,the role of granzyme B in AID remains to be explored.This review summarizes the gene structure,expression regulation,mechanism of granzyme B entry into target cells,and intra-cellular and extracellular functions of granzyme B,and summarizes the role of granzyme B in various AID such as systemic lupus erythematosus,rheumatoid arthritis,systemic sclerosis,vasculitis and idiopathic inflammatory myopathy.The purpose of this review is to summarize the etiology of AID and provide ideas for further research on diagnosis,prevention and prognosis.
Keywords：Autoimmune diseasesGranzyme BCytotoxic T-lymphocyteNatural killer cell
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1596-1600 )