New progress in immunological pathogenesis and targeted therapy of gouty arthritis
Cheng Yaping
Li Xiaoyan
Yan Ni
Abstract：Gouty arthritis is a common crystal-related disease caused by the deposition of sodium urate crystals in articular and non-articular tissues,which can lead to inflammation and joint damage.It is mainly closely related to genetic,environmental and metabolic factors.Its occurrence is usually significantly associated with ele-vated serum uric acid levels.In the presence of persistent hyperuricemia,chronic deposition of sodium urate crys-tals in the joint and periarticular space and subsequent activation of the innate immune system are central mecha-nisms in the development of gouty arthritis.Among them,the exact molecular mechanism of NOD-like receptor family protein 3 inflammasome and some cytokines in the activation of gouty arthritis has not been elucidated.The treat-ment of recurrent gouty arthritis leading to the formation of tophus is limited.Therefore,it is particularly important to find effective drug targets for the treatment of goutv arthritis.
Keywords：Gouty arthritisNOD-like receptor family protein 3 inflammasomeCytokines
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1591-1595 )