Research progress on the relationship between the effect of mechanical stimulation on nucleus pulposus cells and intervertebral disc degeneration
Zhou Yuan
Ma Chongwen
Zhang Yibao
Lei Shuanhu
Kang Xuewen
Abstract：Intervertebral disc degeneration is a complex degenerative disease affected by many factors,and its mechanism still needs to be further explored.Mechanical stimulation has a significant effect on the nucleus pulposus cells in the intervertebral disc,which is of great significance for understanding the mechanism of degeneration and finding treatment strategies.This article summarizes the animal models,new materials,cytoskeleton,cell pathways,mitochondrial damage and aging,and further explores the role and influence of mechanical stimulation on nucleus pulposus cells,so as to provide a more effective and safer treatment plan for lumbar disc degeneration diseases.
Keywords：Intervertebral discMechanical stimulationIntervertebral disc degenerationNucleus pulposus cell
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1586-1590 )