Research progress on the role and mechanism of mitophagy in chronic kidney disease
Zhu Li
Zhang Ting
Qian Jialong
Wang Luyu
Zhou Zhihua
Wang Xin
Zhang Chunsheng
Chen Naihong
Li Gang
Abstract：Mitophagy is an autophagy process in cells that can remove damaged mitochondria and maintain the health of cells.Kidney is an organ with high energy consumption.Mitochondria plays an important role in kidney function,and kidney diseases are usually associated with mitochondrial dysfunction.Recent studies have shown that mitochondrial damage and dysfunction in renal tubular cells may lead to renal tubular injury and decreased glomerular filtration rate,and mitophagy can remove these damaged mitochondria,thereby protecting renal cells from autophagy.In addition,mitophagy is also involved in the occurrence and development of kidney diseases,such as glomerulosclerosis and renal tubulointerstitial fibrosis.Therefore,mitophagy plays an important role in the prevention and treatment of kidney diseases.This article reviews the role of mitophagy in kidney diseases,and provides new ideas and strategies for mitochondrial targeted therapy in the future.
Keywords：MitophagyChronic kidney diseaseSignal pathwayTargeted therapy
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1577-1580 )