Research progress of alveolar macrophages and alveolar epithelial cells in acute respiratory distress syndrome
Shi Yingchang
Zhang Xianming
Abstract：Acute lung injury often leads to the death of critically ill patients with acute respiratory distress syndrome(ARDS),and immune cell infiltration is regarded as an important sign of ARDS.Alveolar macrophages(AMs)are immune cells that play a role in the pathogenesis of ARDS.AMs participate in the development of diseases mainly by interacting with alveolar epithelial cells(AECs).AMs participate in the development of diseases mainly by interacting with alveolar epithelial cells(AECs).In the early stages of ARDS,activated AMs secrete proinflammatory cytokines to remove pathogens that may disrupt the cellular structure of AECs and cause cell death.In the late stage of ARDS,alternatively activated macrophages secrete anti-inflammatory cytokines that inhibit inflammatory responses and promote epithelial regeneration and alveolar structural remodeling.This article mainly reviews the functions and characteristics of AMs and AECs in ARDS,and describes the interaction between AMs and AECs.
Keywords：Acute respiratory distress syndromeAlveolar epithelial cellsAlveolar macrophages
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1568-1572 )