A case study and analysis of the literature on extremely severe lactic acidosis brought on by linezolid
Deng Yang
Li Jinghao
Lu Tingting
Kang Fuxin
Abstract：Linezolid is an oxazolidinone antibacterial drug whose mechanism of action is mainly to inhibit bacterial growth by targeting bacterial ribosomes and interfering with bacterial protein synthesis,and is mainly used for the treatment of gram-positive bacteria,including Enterococcus faecalis,Staphylococcus aureus,and Staphylococcus aureus resistant to vancomycin.Although linezolid is an effective antimicrobial drug,its potential to cause lactic acidosis is a rare and fatal side effect.Current treatment guidelines have some recommendations.First,monitor blood linezolid and lactate levels while linezolid is being administered.Second,linezolid should not be combined with drugs that affect mitochondrial function.Third,patients with hepatic and renal insufficiency or linezolid therapy for＞1 month should be monitored for hyperlactatemia.Fourth,if hyperlactic acidosis occurs,it is recommended to stop linezolid and correct the acidosis as soon as possible.This article reports a case of lactic acidosis after taking linezolid for tuberculous pleurisy,which was confirmed to be a side effect of linezolid after exclusion of other causes such as metabolism,hypoxia or organ damage.It aims to improve clinicians'knowledge of the diagnosis and treatment of lactic acidosis caused by linezolid.
Keywords：LinezolidLactic acidosisTuberculous pleurisyShock
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1547-1549 )