Effect of Huayu Xiaozhong decoction on early functional rehabilitation and blood related indexes after total knee arthroplasty

Cai Jun; Lu Liaodong; Yu Ximing; Wang Dongwei

doi:10.3760/j.issn.1673-4777.2024.10.021

Abstract：Objective To explore the effects of Huayu Xiaozhong decoction on early functional rehabilitation and blood related indexes in patients after total knee arthroplasty(TKA).Methods The medical records of 220 patients who underwent TKA in the Department of Orthopedics,Liaocheng Hospital of Traditional Chinese Medicine,Shandong Province from June 2023 to April 2024 were collected.The patients were divided into control group(103 cases)and observation group(117 cases)according to whether they took Huayu Xiaozhong decoction after operation.The general data,improvement of joint function,improvement of joint swelling and pain,serum indexes,and incidence of deep vein thrombosis of lower extremities were compared between the two groups.Results There were no significant differences in gender,age,body mass index and surgical side between the control group and the observation group(all P＞0.05).The knee joint function(HSS)score and knee range of motion of the two groups at 1 week after operation were lower than those before operation,and the HSS score and knee range of motion at 2 weeks and 1 month after operation were higher than those before operation(all P＜0.05).The HSS score and knee range of motion of the observation group were higher than those of the control group at 1 week,2 weeks and 1 month after operation(all P＜0.05).There were no significant differences in knee circumference between the two groups at each time point(all P＞0.05).The visual analogue scale(VAS)scores of the two groups at 1 week,2 weeks and 1 month after operation were lower than those before operation,the VAS scores of the observation group at 1 week and 2 weeks after operation were lower than those of the control group,and the VAS score of the observation group at 1 month after operation was higher than that of the control group(all P＜0.05).In the control group,the levels of D-dimer at 1 week and 2 weeks after operation,high-sensitivity C-reactive protein(hs-CRP)at 1 week,2 weeks and 1 month after operation,and interleukin-6(IL-6)at 1 week after operation were higher than those before operation,and the levels of IL-6 at 2 weeks and 1 month after operation were lower than those before operation(all P＜0.05).The levels of D-dimer,hs-CRP and IL-6 in the observation group at 1 week,2 weeks and 1 month after operation were higher than those before operation,and the levels of IL-6 in the observation group at 2 weeks and 1 month after operation were lower than those before operation(all P＜0.05).The levels of hs-CRP and IL-6 in the observation group were lower than those in the control group at 1 week and 2 weeks after operation,and the levels of IL-6 in the observation group at 1 month after operation were lower than those in the control group(all P＜0.05).The incidence of deep vein thrombosis of lower extremities in the observation group was lower than that in the control group[4.3％(5/117)vs 6.8％(7/103)],but the difference was not statistically significant(x2=0.676,P=0.411).Conclusions The application of Huayu Xiaozhong decoction after TKA can reduce the level of serum inflammatory factors in the early postoperative period,reduce the inflammatory response and relieve knee pain,so as to improve the range of motion of the joint,improve the joint function score,and promote the purpose of early postoperative rehabilitation.