Clinical effect of Yishen Huashi granule combined with semaglutide in the treatment of diabetic nephropathy and its effect on microinflammatory state of patients
Li Jianjun
Yan Junhui
Sun Yingchun
Liu Yushuo
Yang Zaibo
Abstract：Objective To investigate the effect of Yishen Huashi granule combined with semaglutide in the treatment of diabetic nephropathy(DN)and its effect on microinflammatory state of patients.Methods A total of 220 DN patients admitted to Peking University Third Hospital Qinhuangdao Hospital from January 2022 to December 2023 were selected as the research objects.According to the random number table method,they were divided into semaglutide group and combination group,with 110 cases in each group.The semaglutide group was treated with subcutaneous injection of semaglutide injection on the basis of conventional treatment,and the combined group was treated with Yishen Huashi granule on the basis of semaglutide group.The efficacy,glucose and lipid metabolism,renal function,oxidative stress,microinflammatory state indicators and adverse reactions were compared between the two groups.Results The total effective rate of the combination group was higher than that of the semaglutide group[93.6％(103/110)vs 83.6％(92/110)](P=0.019).After treatment,the levels of fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,total cholesterol,low-density lipoprotein cholesterol,serum creatinine,(β2-microglobulin,24 h urinary protein,malondialdehyde,high-sensitivity C-reactive protein,tumor necrosis factor-α and interleukin-6 in the two groups were lower than those before treatment,and those in the combination group were lower than those in the semaglutide group;the levels of high-density lipoprotein cholesterol,glutathione peroxidase and superoxide dismutase were higher than those before treatment,and those in combination group were higher than those in semaglutide group(all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.604).Conclusion Yishen Huashi granule combined with semaglutide is superior to semaglutide alone in the treatment of DN,which can effectively reduce blood glucose and lipid levels of patients,improve micro-inflammatory state,and has good safety.
Keywords：Diabetic nephropathyYishen Huashi granuleSemaglutideMicroinflammatory state
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1536-1540 )