Clinical study on the effect of Bushen Yiqi recipe on bone marrow suppression and immune function after breast cancer chemotherapy

Li Lingsheng; Zhang Yin; Li Fagen; Tang Xiaoran; Wang Yujia; Cui Yixin

doi:10.3760/j.issn.1673-4777.2024.10.019

Abstract：Objective To explore the effect of Bushen Yiqi recipe on bone marrow suppression and immune function after breast cancer chemotherapy.Methods A total of 110 breast cancer patients treated with epirubicin and cyclophosphamide sequential Docetaxel(EC-T)scheme in the Sixth Medical Center of Chinese PLA General Hospital from January 2023 to January 2024 were selected as the research objects.They were randomly divided into the control group and the observation group,with 55 cases in each group.The control group was treated with the EC-T scheme.The observation group was treated with Bushen Yiqi recipe on the basis of the control group.The changes of blood routine indexes,cellular immune function,traditional Chinese medicine symptom score and quality of life score(QLQ-C30)in patients were observed before and after treatment.Results After treatment,the white blood cell count,absolute neutrophil count,hemoglobin and platelet count levels of the two groups were lower than those before treatment,but those in the observation group were higher than those in the control group(all P＜0.05).After the treatment,levels of CD3+,CD4+and CD4+/CD8+ratio of the two groups were lower than those before the treatment,but those in the observation group were higher than those in the control group;the CD8+level was higher than that before the treatment,but that in the observation group was lower than that in the control group(all P＜0.05).After treatment,the scores of shortness of breath,fatigue,palpitation,insomnia,dizziness,complexion,cold limbs,waist and knee soreness in the two groups were higher than those before treatment,but those in the observation group were lower than those in the control group(all P＜0.05).After 7 and 20 d of treatment,the QLQ-C30 scores of the two groups were lower than those before treatment,but the scores in the observation group were higher than those in the control group[(75.2±2.1)vs(74.1±1.9),(78.9±2.2)vs(75.9±2.1)](all P＜0.05).Conclusions Bushen Yiqi recipe can effectively prevent bone marrow suppression after breast cancer chemotherapy,correct the immune dysfunction after chemotherapy,improve the secondary clinical symptoms of patients after chemotherapy,and significantly improve the quality of life.It can be used as an adjuvant and supplementary treatment for breast cancer patients undergoing chemotherapy.