Effect of intranasal dexmedetomidine on emergence agitation during general anesthesia in elderly patients with renal insufficiency
Chang Qian
Hou Guoqing
Yue Hailong
Xu Yanrong
Han Miaomiao
Abstract：Objective To investigate the effect of intranasal dexmedetomidine on emergence agitation during general anesthesia in elderly patients with renal insufficiency.Methods A total of 100 elderly patients with renal insufficiency undergoing gastrointestinal surgery in Tangshan Central Hospital,Hebei Province from February 2023 to February 2024 were selected as the research objects,and were randomly divided into two groups,with 50 cases in each group.Patients in the observation group were given intranasal dexmedetomidine l h before the end of surgery.Patients in the control group were given the same volume of 0.9％sodium chloride injection nasal drops 1 h before the end of surgery.The anesthesia recovery index,pain degree,sedation effect,renal function index and adverse reactions were compared between the two groups.Results The recovery time of spon-taneous breathing and anesthesia recovery time in the observation group were shorter than those in the control group(both P＜0.05).The visual analogue scale scores of the observation group were lower than those of the control group at 6,12,24 h and 48 h after anesthesia recovery(all P＜0.001).The Ramsay scores of sedation immediately,5,30 and 60 min after extubation in the observation group were higher than those in the control group(all P＜0.001).The levels of blood urea nitrogen,serum creatinine,24 h urinary albumin and 24 h urinary microalbumin excretion rate in the observation group were lower than those in the control group(all P＜0.001).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group[8.0％(4/50)vs 46.0％(23/50),x2=18.316,P＜0.001].Conclusion The application of intranasal dexmedetomidine in patients with renal insufficiency undergoing general anesthesia has good anesthetic analgesic and sedative effects,which can effectively shorten the time of respiratory recovery and anesthesia recovery,reduce restlessness during anesthesia recovery,good recovery of renal function level,less adverse reactions,and is safe and effective.
Keywords：Renal insufficiencyDexmedetomidineGeneral anesthesiaEmergence agitation
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1495-1498 )