Impacts of esmolol combined with carvedilol on heart rate-systolic pressure product and serum Sestrin2 level in patients with coronary atherosclerotic heart disease myocardial ischemia

He Gaihong; Li Zhen

doi:10.3760/j.issn.1673-4777.2024.10.004

Abstract：Objective To investigate the impacts of esmolol combined with carvedilol on the heart rate-systolic blood pressure product(RPP)and serum Sestrin2 level in patients with coronary atherosclerotic heart disease(CHD)and myocardial ischemia.Methods A total of 106 patients with CHD and myocardial ischemia admitted to Yulin Hospital,First Affiliated Hospital of Xi'an Jiaotong University from March 2021 to March 2023 were selected.According to the random number table method,they were divided into the observation group and the control group,with 53 cases in each group.The control group was treated with carvedilol,and the observation group was treated with esmolol on the basis of the control group.Both groups were treated for 8 weeks.The total effective rate,electrocardiogram examination results,myocardial oxygen supply related indicators,serum Sestrin2 levels and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group[90.6％(48/53)vs 75.5％(40/53)](P=0.038).After treatment,the total myocardial ischemic load,the number and duration of ST segment depression within 24 h,heart rate,systolic blood pressure and RPP levels in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).After treatment,the serum Sestrin2 levels in both groups were lower than those before treatment,and the serum Sestrin2 level in the observation group was lower than that in the control group[(8.1±1.0)μg/L vs(10.1±1.6)μg/L](all P＜0.001).The total incidence of adverse reactions in the observation group was lower than that in the control group[11.3％(6/53)vs 47.2％(25/53)](P＜0.001).Conclusion The combination of esmolol and carvedilol is effective in the treatment of patients with CHD and myocardial ischemia,which can effectively improve the myocardial ischemia status of patients,regulate heart rate and blood pressure levels,reduce myocardial oxygen consumption,and has fewer adverse reactions.