Analysis of the predictive value of serum proprotein convertase subtilisin/kexin type 9 and lipopolysaccharide for cardiovascular disease death in elderly patients with non-valvular atrial fibrillation
Han Chuhong
Zhong Zanrui
Wang Suimei
Li Tianfa
Abstract：Objective To investigate the predictive value of serum proprotein convertase subtilisin/kexin type 9(PCSK9)and lipopolysaccharide(LPS)for cardiovascular and cerebrovascular disease mortality in elderly patients with non-valvular atrial fibrillation(NVAF).Methods A total of 575 elderly patients with NVAF admitted to Haikou People's Hospital,Hainan Province from October 2016 to December 2020 were selected and followed up for 3 years.They were divided into death group(74 cases)and survival group(501 cases)according to whether they died of cardiovascular and cerebrovascular diseases.The serum levels of PCSK9 and LPS were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the risk factors for cardio-vascular and cerebrovascular disease mortality in elderly NVAF patients.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum PCSK9 and LPS levels for cardiovascular and cerebrovascular disease mortality in elderly NVAF patients.Results After 3 years of follow-up,the cardiovascular and cerebro-vascular disease mortality of 575 elderly NVAF patients was 12.9％(74/575).The serum levels of PCSK9 and LPS in the death group were higher than those in the survival group(all P＜0.001).Multivariate Logistic regres-sion analysis showed that increasing age,increased CHA2DS2-VASc score,acute myocardial infarction,stroke/transient ischemic attack,increased heart failure,increased PCSK9,and increased LPS were the independent risk factors for cardiovascular and cerebrovascular disease death in elderly NVAF patients(all P＜0.05).The ROC curve showed that the area under the curve of serum PCSK9 and LPS levels combined to predict the death of cardio-vascular and cerebrovascular disease in elderly NVAF patients was 0.873,which was larger than 0.781 and 0.795 predicted by serum PCSK9 and LPS levels alone(both P＜0.001).Conclusion Elevated serum PCSK9 and LPS levels are independent risk factors for cardiovascular death in elderly patients with NVAF,and the combination of serum PCSK9 and LPS levels has a high predictive value for cardiovascular death in elderly patients with NVAF.
Keywords：Non-valvular atrial fibrillationProprotein convertase subtilisin/kexin type 9Lipopo-lysaccharideCardiovascular mortality
Publication Date：2024-10-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1451-1455 )