Research progress of T helper cell 17/regulatory T cell and retinoic acid-related orphan receptor γt/forkhead box transcription factor P3 imbalance in pregnancy-related diseases
Yang Chunyan
Feng Xiaoling
Abstract：In the field of immunology,pregnancy is equivalent to a successful semi-allograft phenomenon,and the maternal immune tolerance to the semi-allograft fetus is related to the outcome of pregnancy.Helper T cells 17(Th17)and regulatory T cell(Treg)are newly discovered subsets of CD4+T lymphocytes.The expression levels of related transcription factor retinoic acid-related orphan receptor γt and forkhead box transcription factor P3 are closely related to the balance between Th17/Treg.The Th17/Treg immune imbalance can lead to abnormal maternal attack on the fetus,resulting in maternal-fetal tolerance disorder,and is related to recurrent miscarriage,preeclampsia,gestational diabetes mellitus and other pathological pregnancy.
Keywords：Pregnancy-related diseasesT helper cell 17Regulatory T cellRetinoic acid-related orphan receptor γtForkhead box transcription factor P3
Publication Date：2024-09-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1436-1440 )