The role of tumor-associated macrophages in triple-negative breast cancer and advancements in therapeutic research
Fan Xingxiu
Guo Jianping
Niu Haigang
Abstract：Triple-negative breast cancer(TNBC)is a highly heterogeneous subtype of breast cancer.Due to its lack of specific treatment markers,its recurrence rate,mortality rate,and aggressiveness are all higher than other types of breast cancer.In recent years,the focus of tumor research has been on the tumor microenvironment,and tumor-associated macrophages(TAM)account for more than 50％of the stromal cells in breast cancer and are the most abundant immune cells in the tumor microenvironment.A large number of studies on the relationship between TAM and tumor-related mechanisms have found that TAM play an important role in tumor development and progression,making them a promising biomarker for TNBC treatment and prognosis prediction.This review summa-rizes the role of TAM in TNBC and potential treatment strategies.
Keywords：Triple-negative breast cancerTumor-associated macrophagesNeoadjuvant therapy
Publication Date：2024-09-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1416-1420 )