Short-term effect study of Guyuling capsules combined with calcitriol in the treatment of osteoporosis

Wang Yang; Zhao Ru; Wei Xiaoqian; Wang Xin; Yang Dan; Li Hui

doi:10.3760/j.issn.1673-4777.2024.09.020

Abstract：Objective To investigate the short-term effect of Guyuling capsules combined with calcitriol in the treatment of osteoporosis.Methods A total of 90 patients with osteoporosis admitted to Shaanxi Provincial People's Hospital from April 2022 to October 2023 were selected.They were divided into control group and observation group using the random number table method,with 45 cases in each group.The control group received treatment with calcitriol on the basis of routine symptomatic support,and the observation group was given treatment of Guyuling capsules on the basis of the control group.Both groups were treated continuously for 6 months.The total effective rate,pain visual analogue scale(VAS)score,brief health status survey scale(SF-36)score,lumbar spine anteroposterior(L1-4)and left femoral neck bone density,bone metabolism indicators[osteoprotegerin,osteocalcin,C-telopeptide of type Ⅰ collagen(CTX-Ⅰ),and bone alkaline phosphatase(BALP)]levels before and after treatment were compared,as well as the incidence of adverse reactions during treatment was compared.Results The total effective rate of the observation group was higher than that of the control group[95.6％(43/45)vs 75.6％(34/45)],and the difference was statistically significant(P=0.007).After treatment,the SF-36 score,serum osteoprotegerin,osteocalcin,and BALP levels,lumbar vertebrae(L1-4)and left femoral neck bone density in the observation group were higher than those in the control group,while VAS score and CTX-Ⅰ level were lower than those in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between observation group and control group[8.9％(4/45)vs 4.4％(2/45)](P=0.398).Conclusions The combination of Guyuling capsules and calcitriol has a significant short-term effect on the treatment of osteoporosis,which may be achieved by improving bone density and bone metabolism levels,and has good safety.