Effect of intrapulmonary oscillation and lung expansion in the treatment of acute exacerbation of chronic obstructive pulmonary disease

Xue Xiang; Zhao Wei; Jia Ling; Yang Jinghui; Cai Jianqin; Chen Kunlun; Chen Jiao

doi:10.3760/j.issn.1673-4777.2024.09.010

Abstract：Objective To investigate the therapeutic effect of intrapulmonary oscillation and lung expansion(OLE)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 108 AECOPD patients admitted to the Department of Critical Care Medicine,Sir Run Run Hospital,Nanjing Medical University from April 2022 to December 2023 were selected as the research objects.The patients were divided into observation group and control group by random number table method,with 54 cases in each group.The control group was given conventional chest physical therapy.The observation group was treated with OLE.Sputum volume,partial pressure of oxygen,partial pressure of carbon dioxide,respiratory rate,heart rate,forced expiratory volume in the first second(FEV1),ratio of FEV1to forced vital capacity(FEV1/FVC)and percentage of FEV,to predicted value(FEV1％)were compared between the two groups at the 1,3 and 5 d after treatment.The utilization rate of non-invasive ventilator(NIV),length of stay in intensive care unit(ICU)and 28 d mortality were compared between the two groups.Results The sputum volume of the observation group was higher than that of the control group 1 and 3 d after treatment,and was lower than that of the control group 5 d after treatment(all P＜0.05).At the 1,3 and 5 d after treatment,the partial pressure of oxygen in the two groups increased,and in the observation group was higher than that in the control group,and the partial pressure of carbon dioxide,respiratory rate and heart rate in the two groups decreased,and in the observation group were lower than those in the control group.At the 1,3 and 5 d after treatment,FEV1,FEV1/FVC and FEV1％in the two groups increased,and those in the observation group were higher than those in the control group at each time point(all P＜0.05).The utilization rate of NIV and the length of ICU stay in the observation group were lower/shorter than those in the control group[11.1％(6/54)vs 24.1％(13/54),(6.2±2.2)dvs(8.5±3.8)d](both P＜0.05).There was no significant difference in 28 d mortality between the observation group and the control group[1.9％(1/54)vs3.7％(2/54)](x2=1.025,P=0.074).Conclusion OLE can promote sputum excretion,improve oxygenation and ventilation function,reduce the utilization rate of NIV and shorten the length of ICU stay in patients with AECOPD.