Study on the value of lung ultrasound combined with interleukin in the diagnostic and prognostic evaluation of neonatal infectious pneumonia

Wang Yan; Wang Xiaoying; Lei Yan

doi:10.3760/j.issn.1673-4777.2024.09.008

Abstract：Objective To investigate the diagnostic and prognostic evaluation value of lung ultrasound combined with interleukin-23(IL-23)and interleukin-17 in neonatal infectious pneumonia.Methods A total of 124 neonates with infectious pneumonia admitted to Shijiazhuang People's Hospital,Hebei Province from June 2020 to August 2023 were selected as the pneumonia group.According to the neonatal critical illness score,they were divided into non-critical group(＞90,72 cases)and critical group(≤90,52 cases).Another 124 neonates hospitalized for jaundice without pulmonary complications during the same period were selected as the control group.According to the ultrasound examination and symptoms after 7 d of treatment,the neonates with infectious pneumonia were divided into good prognosis group and poor prognosis group.All children underwent lung ultrasound examination after admission to evaluate the lung ultrasound score,and the serum levels of IL-23 and IL-17 were measured by enzyme-linked immunosorbent assay.The lung ultrasound scores and serum levels of IL-23 and IL-17 in each group were compared.The receiver operating characteristic(ROC)curve was used to analyze the value of the above indexes in the diagnostic and prognostic evaluation of neonatal infectious pneumonia.Results The lung ultrasound score and serum levels of IL-23 and IL-17 in the pneumonia group were higher than those in the control group(all P＜0.05).The lung ultrasound score and serum levels of IL-23 and IL-17 in the critical group were significantly higher than those in the non-critical group(all P＜0.05).The lung ultrasound score and serum levels of IL-23 and IL-17 in the good prognosis group were significantly lower than those in the poor prognosis group(all P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of lung ultrasound score combined with IL-23 and IL-17 in the diagnosis of neonatal infectious pneumonia was 0.901,which was significantly larger than that of each index alone(Z=4.209,3.492,3.748,all P＜0.05).The AUC of the combination of the three indicators in evaluating the prognosis of neonatal infectious pneumonia was 0.954,which was significantly larger than that of each indicator alone(Z=2.472,2.048,2.839,all P＜0.05).Conclusion The lung ultrasound scores and serum levels of IL-23 and IL-17 were significantly increased in the neonates with infectious pneumonia,and the levels of them were closely related to the severity and prognosis of the disease.The combination of the three methods has better efficacy in the diagnosis and prognosis evaluation of neonatal infectious pneumonia.