Effect of perioperative hydration therapy combined with furosemide on contrast-induced nephropathy after percutaneous coronary intervention and its safety evaluation
Tilakezi Tuersun
Tuerxunnayi Aihaiti
Feng Wei
Yang Heyin
Zainuremu Tuerdi
Abstract：Objective To investigate the effect and safety of perioperative hydration therapy combined with furosemide on contrast-induced nephropathy(CIN)after percutaneous coronary intervention(PCI).Methods A total of 556 patients who underwent PCI in the Department of Cardiology,the First People's Hospital of Kashi,Xinjiang Uygur Autonomous Region from January to December 2023 were collected.All patients were divided into control group and observation group by random number table method,with 278 cases in each group.The observation group was treated with hydration and furosemide during the perioperative period,and the control group was treated with hydration alone.The basic clinical data of the two groups were compared.The renal function and the incidence of CIN were compared before and after operation.The influencing factors of CIN were analyzed by binary Logistic regression.The incidence of adverse reactions during hospitalization was compared between the two groups.Results The proportion of male in the observation group was lower than that in the control group,and the proportion of hypertension history,contrast agent dosage,and proportion of taking β-blockers were higher than those in the control group(all P＜0.05).The levels of serum creatinine,cystatin C and serum uric acid in the two groups were significantly higher than those before operation(all P＜0.05).The incidence of CIN in the observation group was lower than that in the control group[19.4％(54/278)vs 27.3％(76/278)](P=0.027).Binary Logistic regression analysis showed that contrast agent dosage was an independent risk factor for CIN after PCI(odds ratio=1.016,95％confidence interval:1.009-1.024,P=0.019).Furosemide was a protective factor for CIN after PCI(odds ratio=0.359,95％confidence interval:0.143-0.904,P=0.030).There was no significant difference in the incidence of adverse reactions between the two groups during hospitalization(P=0.102).Conclusion Perioperative hydration combined with furosemide can reduce the incidence of CIN after PCI,and does not increase the incidence of adverse reactions during hospitalization,with high safety.
Keywords：Percutaneous coronary interventionContrast induced nephropathyHydration therapyFurosemide
Publication Date：2024-09-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1294-1298 )