Predictive value of stress hyperglycemia ratio for the prognosis of patients with peripartum cardiomyopathy

Zhu Jiajia; Liu Wenxian; Chen Liying; Liu Baoli

doi:10.3760/j.issn.1673-4777.2024.09.002

Abstract：Objective To investigate the prognostic value of stress hyperglycemia ratio(SHR)in patients with peripartum cardiomyopathy(PPCM).Methods The clinical data of 78 patients diagnosed with PPCM in Beijing Anzhen Hospital,Capital Medical University from January 2007 to March 2023 were collected and retrospectively analyzed.According to the improvement of cardiac function,the patients were divided into non-improvement group(37 cases)and improvement group(41 cases).The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of SHR for poor prognosis of patients,and Logistic regression analysis was used to evaluate the influencing factors of no improvement of cardiac function.Results The age,proportion of multipara,proportion of PPCM history,left ventricular end diastolic diameter,serum creatinine,blood glucose,B-type natriuretic peptide and SHR in the non-improvement group were larger/higher than those in the improvement group,while systolic blood pressure and left ventricular ejection fraction(LVEF)were lower than those in the improvement group(all P＜0.05).The ROC curve analysis results showed that the optimal cut-off value of SHR for predicting poor prognosis in patients with PPCM was 1.079,the sensitivity was 81.1％,the specificity was 90.2％,and the area under the curve was 0.880(95％confidence interval:0.800-0.961)(P=0.041).Multivariate Logistic regression analysis results showed that SHR≥1.079,serum creatinine and LVEF＜35％were independent risk factors for poor prognosis in patients with PPCM(all P＜0.05).Conclusion SHR ≥ 1.079 is a risk factor for poor prognosis in PPCM patients,and the use of SHR can assist in identifying high-risk populations for PPCM.