Quantitative analysis of echocardiographic parameters for prenatal screening of atrioventricular septal defect
Zhou Xiaoxue
Ruan Yanping
Zhang Ye
Han Jiancheng
Gu Xiaoyan
Zhao Ying
He Yihua
Abstract：Objective This study aimed to select the critical parameters for prenatal screening of atrioven-tricular septal defect(AVSD)through analyzing the quantitative parameters of fetal echocardiography(FE).Methods Totally 112 FE quantitative parameters of 96 AVSD fetuses and 370 normal fetuses diagnosed in our center between January 2016 and December 2021 were retrospectively analyzed.Based on the area under the receiver operating characteristic curve(AUC),the top six with the best screening effect were selected and the effectiveness of six parameters was analyzed.Results Among the 112 parameters,the top six with the largest AUC were the end diastolic atrioventricular length ratio,the quantile score(Q score)of the end diastolic atrioven-tricular length ratio,the Q score of the end systolic atrioventricular length ratio,the end systolic atrioventricular length ratio,Q score of the end diastolic ventricular length,and the end-diastolic ventricular length.The AUC were 0.92,0.92,0.86,0.84,0.84 and 0.81,respectively.Within the range of false positive rate of 20％,the sensitivities of six parameters for prenatal screening of AVSD were 82％,82％,75％,67％,65％and 71％,respectively.Conclusion The ratio of the end diastolic atrioventricular length and its Q score could be used as the critical parameters for prenatal screening of AVSD,with the former being easier to calculate and remember.
Keywords：Atrioventricular septal defectFetusEchocardiographyQuantitative parameters
Publication Date：2024-08-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1150-1154 )