Research progress on the relationship between microRNAs and the diagnosis,treatment and prognosis evaluation of heart failure
Yang Yifei
Lyu Zhenyu
Jin Mei
Abstract：Heart failure is a complex and common endpoint of many cardiovascular diseases,caused by various types of heart disease.MicroRNA(miR)is a class of endogenous non-coding small RNA molecules with a length of about 22 nucleotides,which can regulate the growth,differentiation,proliferation,apoptosis and other life activities of cells.A large number of studies have shown that miR is involved in the occurrence and development of a variety of heart failure,such as cardiomyocyte hypertrophy,myocardial fibrosis,and abnormal cardiac energy metabolism,and miR has a specific expression profile in various cardiovascular diseases,indicating that miR is expected to become a new biomarker for cardiovascular diseases.In addition,more than 60 miR-based therapeutic drugs are currently in different stages of development,such as targeting miR mimics or antagonists,miR inhibitors and other ways to regulate endogenous miR levels.The miR may be a potential target for new therapeutic strategies.This review summarizes the relationship between miR and the diagnosis,treatment and prognosis of heart failure.
Keywords：Heart failureMicroRNADiagnosis and treatmentPrognostic evaluation
Publication Date：2024-07-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1079-1082 )