Efficacy and health economics evaluation of different minocycline-containing quadruple regimens in newly treated patients with Helicobacter pylori infection
Si Xiaobei
Chen Xiaolu
Zhang Lingyun
Shi Yanyan
Lan Yu
Ding Shigang
Abstract：Objective To evaluate the efficacy and health economics of different minocycline-containing quadruple regimens in newly treated patients with Helicobacter pylori(Hp)infection.Methods From January 1,2022 to July 31,2023,the clinical data of 554 Hp infection patients who received eradication treatment with a quadruple regimen containing minocycline in Beijing Jishuitan Hospital,Capital Medical University were retrospectively analyzed.According to different eradication treatment plans,they were divided into MAPB group(166 cases),MMPB group(81 cases),and MLPB group(307 cases).The MAPB group received minocycline-amoxicillin-proton pump inhibitor(PPI)-bismuth regimen,the MMPB group received minocycline-metronidazole-PPI-bismuth regimen,and the MLPB group received minocycline-levofloxacin-PPI-bismuth regimen,All three groups were treated for 14 d.Outcome measures included Hp eradication rate and incidence of adverse reactions.Using the results of the above studies as parameters,multi-strategy comparison and net benefit method were used to evaluate all treatment strategies and screen the superior one,respectively.Sensitivity analysis was performed to evaluate the stability of the results.Results The Hp eradication rates of patients in the MAPB group,MMPB group,and MLPB group were 92.8％(154/166),84.0％(68/81),and 94.1％(289/307)(x2=9.382,P=0.009).Adverse drug reactions were reported in 185 of 554 patients(33.4％)during eradication therapy.The incidence of adverse events(46.9％)was highest in MMPB group(x2=38.545,P＜0.001).The results of multi-scheme comparison showed that none of the above three schemes was absolutely inferior.The multi-scheme comparison method and the net benefit method results showed that minocycline-levofloxacin-PPI-bismuth regimen might be advantage intervention.Sensitive analysis showed that eradication rate of minocycline-amoxicillin-PPI-bismuth regimen had significant impact on stability of such result.Conclusions Minocycline-containing quadruple therapies showed satisfactory efficacy in the eradication treatment of newly treated patients with Hp infection.Minocycline-levofloxacin-PPI-bismuth regimen might stand optimal health economic value.
Keywords：Helicobacter pylori infectionMinocyclineHealth economics evaluation
Publication Date：2024-07-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1019-1023 )