Serum biomarker changes and clinical significance after patent foramen ovale closure

Ye Su; Huang Haojia; Hu Haibo; Pan Xiangbin; Zhang Fengwen; Lyu Jianhua

doi:10.3760/j.issn.1673-4777.2024.07.007

Abstract：Objective To investigate the changes of serum markers after patent foramen ovale(PFO)closure and its clinical significance.Methods A total of 210 patients who underwent PFO closure in Fuwai Hospital,Chinese Academy of Medical Sciences from December 2019 to October 2022 were included retrospectively.The levels of serum markers before and after occlusion were compared,including the neutrophil/lymphocyte(NLR),the platelet/lymphocyte(PLR),mean platelet volume(MPV),homocysteine(Hey),albumin,total cholesterol,and high-density lipoprotein cholesterol levels.PFO patients with stroke were selected as the observa-tion group(151 cases),and 149 patients with atrial septal defect in our hospital during the same period were selected as the control group.The Hey levels were compared between the observation group and the control group before and after occlusion.Results The levels of NLR,PLR,and MPV in patients after occlusion were higher than those before occlusion,while the levels of Hey,albumin,total cholesterol,and high-density lipoprotein cholesterol were lower than those before occlusion(all P＜0.05).The Hey level in the observation group before PFO closure was significantly higher than that in the control group[(13.11±10.15)μmol/L vs(10.38±3.44)μmol/L](P＜0.01).There was no significant difference in Hcy level between the observation group[(11.12±9.68)μmol/L]after occlusion and the control group(P＞0.05).Conclusion The level of Hey significantly decreased after PFO closure,and high level of Hey may be closely related to PFO-associated crypto-genic stroke.In conclusion,it is clinically meaningful to monitor the Hey level in patients with PFO.