The effect of intensive atorvastatin on the short-term efficacy of patients with ischemic heart failure and ferroptosis pathway proteins
Lan Youling
Li Tianfa
Chen Yan'e
Guan Fuqing
Yang Yang
Zhan Yatong
Abstract：Objective To investigate the short-term efficacy of atorvastatin on patients with ischemic heart failure and its effect on the expression of ferroptosis signaling pathway related proteins.Methods A total of 124 patients with ischemic heart failure diagnosed in the First Affiliated Hospital of Hainan Medical University from January 2021 to October 2022 were selected.The patients were randomly divided into control group and observation group,with 62 cases in each group.The control group was treated with conventional drugs and interventional therapy,and the observation group was treated with atorvastatin on the basis of the control group.The incidence of major adverse cardiac events(MACE),heart failure indicators,oxidative stress indicators,blood lipid indicators and ferroptosis pathway proteins were compared between the two groups.Results The total incidence of MACE in the observation group was lower than that in the control group[6.5％(4/62)vs 19.4％(12/62)](x2=4.593,P=0.032).After 1 month of treatment,the left ventricular ejection fraction of the control group was higher than that before treatment,and the brain natriuretic peptide was lower than that before treatment;the left ventricular ejection fraction and superoxide dismutase in the observation group were higher than those before treatment,and the brain natriuretic peptide and malondialdehyde were lower than those before treatment;the superoxide dismutase in the observation group was higher than that in the control group,and the malondialdehyde was lower than that in the control group(all P＜0.05).After 1 month of treatment,the levels of total cholesterol,low-density lipoprotein cholesterol and lipoprotein a in the observation group were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).After 1 month of treatment,the levels of nicotinamide adenine dinucleotide phosphate(NADPH)and glutathione,and the protein expression of glutathione peroxidase 4,quinone oxido-reductase 1 and solute carrier family 7 member 11 in the observation group were higher than those before treatment,and those in the observation group were higher than those in the control group;the levels of non-heme iron and the protein expression of NADPH oxidase 2 were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).Conclusion Routine use of atorvastatin in the treatment of ischemic heart failure can improve the short-term efficacy,which may be related to lowering blood lipids,anti-oxidative stress and inhibiting the active expression of ferroptosis signaling pathway.
Keywords：Ischemic heart failureAtorvastatinFerroptosisOxidative stress
Publication Date：2024-07-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 980-984 )