Research progress of intestinal flora and its metabolites in diabetic nephropathy
Zhang Qing
Wang Jianqin
Abstract：Diabetic nephropathy(DN)is an important cause of end-stage renal disease,but its mechanism is not fully understood.At present,it is considered to be the result of the interaction of genetics,immunity,inflammation,insulin resistance,oxidative stress and other factors.Recent studies have found that there are differences in intestinal flora between DN patients and healthy people,and intestinal flora can participate in the progression of DN by releasing endotoxin and its harmful metabolites to mediate systemic and renal inflammation.Therefore,exploring the role of intestinal flora in renal lesions of DN patients is expected to provide new ideas for the diagnosis and treatment of DN.
Keywords：Diabetic nephropathyIntestinal floraMetabolitesInflammation
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 951-955 )