Overview of pathogenesis and treatment of myasthenia gravis and progress of research on the application of antibody drugs
Ou Ruiyang
Abstract：Myasthenia gravis(MG)is an acquired autoimmune disease,the main symptom of which is the weakness of skeletal muscle contraction caused by neuromuscular transmission disorders.Common treatment methods for MG include anticholinesterase drug therapy,corticosteroid therapy,immunosuppressive therapy,plasma exchange therapy,surgical therapy,etc.Among them,there are various drugs commonly used for MG,such as glucocorticoids,azathioprine,immunosuppressants,etc.,which have been confirmed to have certain curative effects.With the in-depth research of MG mechanism and drugs in the medical community and the development of biotechnology,especially the birth of antibody drugs such as neonatal Fc receptor target antibody drugs,anti-complement 5 antibody drugs and surface antigen-antibody drugs,drug regimen of MG has brought more scientific and effective treatment options.This paper provides an overview of the incidence and treatment of MG,and reviews the research progress of antibody drugs in MG therapy.
Keywords：Antibody drugsAntigenMyasthenia gravis
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 928-932 )