Effect of Xiaoke Jianpi decoction combined with conventional treatment and ketogenic diet management in patients with type 2 diabetes mellitus with Qi and Yin deficiency syndrome
Wei Chenxi
Yan Lixin
Yang Yang
Gao Tongxin
Ye Haiyan
Abstract：Objective To observe the clinical efficacy of Xiaoke Jianpi decoction combined with conven-tional treatment and ketogenic diet management in patients with type 2 diabetes mellitus(T2DM)with Qi and Yin deficiency syndrome.Methods A total of 120 T2DM patients with Qi and Yin deficiency syndrome admitted to Beijing Rehabilitation Hospital,Capital Medical University from March 2021 to March 2023 were enrolled,and they were divided into control group and observation group according to the random number table method,with 60 cases in each group.The control group was given routine treatment and ketogenic diet management,and the observation group was treated with Xiaoke Jianpi decoction on the basis of the control group.Both groups were treated for 12 weeks.The blood glucose index,blood lipid index,inflammatory index,intestinal flora index,clinical efficacy and adverse reactions were compared between the two groups before and after treatment.Results There were 2 cases dropped off in the control group and 1 case dropped off in the observation group.Finally,58 cases in the control group and 59 cases in the observation group completed this study.After treatment,the levels of fasting plasma glucose,2 h postprandial plasma glucose,hemoglobin A1c,tri acylglycerol,total cholesterol,low-density lipoprotein cholesterol,hypersensitive C-reactive protein,tumor necrosis factor-α,interleukin-6,and Enterococcus abundance in the observation group were lower than those in the control group,and the contents of Bifidobacterium abundance and Lactobacillus abundance in the observation group were higher than those in the control group(all P＜0.05).The total effective rate of the observation group was better than that of the control group[93.2％(55/59)vs 77.6％(45/58)],the total incidence of adverse reactions in the observation group was lower than that in the control group[8.5％(5/59)vs 27.6％(16/58)](both P＜0.05).Conclusion Xiaoke Jianpi decoction combined with conventional treatment and ketogenic diet management can effectively improve glucose and lipid metabolism,reduce inflammatory response and regulate intestinal flora in T2DM patients with Qi and Yin deficiency syndrome,with good efficacy and high safety.
Keywords：Type 2 diabetes mellitusQi and Yin deficiency syndromeXiaoke Jianpi decoctionKetogenic diet management
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 904-908 )