Clinical study of Xinkeshu capsules combined with enalapril maleate folic acid tablets in the treatment of H-type hypertension with left ventricular hypertrophy

Zhang Zhengnan; He Wenbo

doi:10.3760/j.issn.1673-4777.2024.06.022

Abstract：Objective To investigate the efficacy and safety of Xinkeshu capsules combined with enalapril maleate folic acid tablets in the treatment of patients with H-type hypertension with left ventricular hypertrophy(LVH).Methods Totally 168 patients with H-type hypertension with LVH admitted to Wuhan University of Science and Technology Affiliated Geriatric Hospital from January 2021 to October 2022 were selected.According to the random number table method,patients were divided into control group(84 cases)and observation group(84 cases).The control group patients were treated with enalapril maleate folic acid tablets,while the observation group patients were treated with Xinkeshu capsules on the basis of the control group.Both groups were treated for 6 months.The treatment efficacy,the systolic blood pressure(SBP),diastolic blood pressure(DBP),homocysteine,and cardiac function indicators before and after 6 months of treatment of two groups were compared.The occurrence of adverse reactions in two groups were counted.Results The total effective rate of the observation group was higher than that of the control group[94.0％(79/84)vs 83.3％(70/84)](P=0.028).After 6 months of treatment,levels of SBP,DBP,and homocysteine in the two groups were significantly reduced,and the levels in the observation group were lower than those in the control group(all P＜0.05).After 6 months of treatment,the left ventricular posterior wall thickness and interventricular septal thickness in the two groups slightly decreased,but there was no statistically significant difference between the groups and within the group(all P＞0.05).After 6 months of treatment,the left ventricular mass index(LVMI)and left ventricular end diastolic diameter(LVEDD)in the two groups significantly decreased,and LVMI and LVEDD in the observation group were greater than those in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the control group and observation group[7.1％(6/84)vs 8.3％(7/84)](P=0.773).Conclusions The combination of Xinkeshu capsules and enalapril maleate folic acid tablets has a good antihypertensive effect on patients with H-type hypertension complicated with LVH.It can also significantly improve left ventricular function,reduce serum homocysteine level,and has high safety.